1. All poor oral exposure issues can be mitigated by optimizing the solid for m of the drug substance and/or the formulation.
- True
- False
2. What is the T50% of gastric emptying of a glass of water (240 ml)?
- Approximately 15 min.
- Approximately 20 min.
- Approximately 30 min.
3. Which of the following is false:
- Primary active transporters are directly coupled to an energy yielding process.
- Secondary active transporters are indirectly coupled to the free energy yielding process via the utilization of the voltage or ion gradients generated by a primary active transporter.
- Na+ symporters are frequent in eukaryotic cells and are an example of secondary active transporters.
- All carrier-mediated transport is active transport.
4. High intrinsic hepatic clearance always translates into high in vivo hepatic clearance. No need to consider differences in microsomal and plasma protein binding.
- True
- False
5. In early discovery, a series of compounds within a chemotype exhibited poor bioavailability in rats. Which of the following studies would shed light on the underlying factors?
- Assessment of solubility in simulated gastric and intestinal media
- Studies in portal vein cannulated rats looking at portal and systemic drug concentrations
- Studies in aminobenzotriazole-treated rats (inhibits CYP-mediated metabolism)
- All of the above
6. What is not a method for producing amorphous dispersion formulations?
- Hot melt extrusion
- Solvent casting
- Spray drying
- Flash freezing
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ANSWERS: B, A, D, B, D, D