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Don’t miss out on the opportunity to expand your knowledge by taking an AAPS eCourse and save 15 percent. This discount applies to the most popular AAPS eCourses, including:
Essentials of Regulatory Affairs
This comprehensive AAPS online training course was developed for those interested in learning more about the field of regulatory affairs from the perspective of a pharmaceutical scientist. This course will discuss the expansion of marketing pharmaceutical products in emerging markets such as Brazil, Russia, India, and China and how global regulations impact the current drug development process. This ecourse features the following:
- The mission and structure of the U.S. Food and Drug Administration and how to stay informed in a field that is constantly evolving.
- Essential knowledge required to navigate through the complex regulatory environment.
- Objectives of various areas such as clinical development and submission.
- The development process and the regulations that govern development, manufacturing, and distribution.
- Global regulations’ impact on the drug development process.
Formulation Strategies for Oral Delivery of Poorly Soluble Drugs
This ecourse provides an overview of formulation strategies of poorly soluble drugs for drug dissolution enhancement. The presentations, delivered by key thought leaders, highlight fundamental principles and enabling technologies for solubility enhancement.
This ecourse introduces the topic and dives deeper into three key areas:
- Solid Formulations
- Liquid Formulations
- Regulatory Aspects
Transporter Knowledge for New Frontiers
This ecourse provides a detailed overview on key concepts in transporter pharmacology that are essential for academic, industrial, and regulatory pharmaceutical scientists.
Transporters are critical determinants of both tissue drug disposition and drug efficacy. Over the past several years, multiple uptake and efflux transporters have been identified and characterized. Advances in molecular pharmacology have shown that transport systems are extremely dynamic and can be modulated by disease and drugs themselves. Furthermore, genetic differences in transporters can contribute to vastly different pharmacokinetic and/or pharmacodynamic profiles within human populations. In addition to their involvement in drug disposition, transporters can also contribute to clinically significant drug-drug interactions.
Preformulation 101
A fundamental role of formulation scientists is to convert candidate drugs into drug products. Achieving this goal requires a thorough understanding of a drug’s pharmaceutical properties. This ecourse will provide fundamentals of the preformulation studies and how the physicochemical, physicomechanical, and biopharmaceutical properties data generated during these studies can impact:
- candidate selection,
- formulation design,
- choice of drug delivery technology,
- drug product manufacturing process,
- pharmacokinetic/biopharmaceutical properties of the resulting product,
- stability of the drug substance and drug product,
- choice of the analytical techniques, and
- packaging of the product.
Participants will acquire an understanding of the role of preformulation in formulation development, gain familiarity with the main tasks performed in preformulation space, and should be able to perform the following:
Select the appropriate physical form of the drug substance and material properties and determine physicochemical and biopharmaceutical properties (e.g., pKa, LogD, MP, Tg, solubility and dissolution in pharmaceutical and biorelevent solvents, permeability, chemical and physical stability, and mechanism of degradation) for a given drug substance and drug product.
Evaluate excipient compatibility studies including physicomechanical impact on stability, prototype formulations, bioperformance evaluation, bioavailability enhancement through solubilization approaches, and on-site formulation development for a given drug product.
Save 15% on all AAPS ecourses! Use promo code NEWSMAGPROMO at checkout to receive your discount.