Cover Stories

Microdialysis can reveal pharmacokinetics and physiological changes in tissue. By Benjamin Kuzma, Long Island University, and Nimita Dave, AbbVie Microdialysis is a powerful semi-invasive technique that enables continuous measurement of local drug, ...

Granule Formation Mechanisms: Twin-screw Continuous Granulation The twin-screw extruder (TSE) is available in a variety of configurations with the corotating, intermeshing, twin-screw extruder being the most commonly used for granulation applications. ...

Ensuring consistent clinical performance. By Kenneth Norris, Pfizer Inc.; Dorys Argelia Diaz, Pfizer Inc.; Mohan Ganapathy, Merck & Co. Inc.; Lynn Gold, Camargo Pharmaceutical Services; and Ling Zhang, Pfizer Inc. What progress has been made on establishing ...

Increasing complexity in oncology clinical trials raises challenges for clinical pharmacologists. By Konstantine W. Skordos, Ph.D., Translational Clinical Oncology, Novartis Institutes for BioMedical Research Preclinical and early clinical development ...

Micro/nanoparticles show promise for immunotherapy against cancer. By Lipika Chablani, Ph.D., St. John Fisher College Formulation scientists are constantly challenged with unique opportunities to deliver chemotherapeutic drug molecules to cancer ...