How Much Do You Know About Formulation?

1. From a formulation performance point of view, the bioavailability of a BCS class II drug can be expected to be primarily a reflection of the ___ of the drug:

1. thermodynamic solubility
2. intrinsic solubility
3. kinetic solubility
4.  melting point

1. different crystal properties of the two compounds
2. different hydrophobicity of the two compounds
3. a combination of a) and b) above
4. neither a) nor b) above

3. Among the commonly used drug solubilization approaches listed below, select the one for which the “like dissolves like” principle can be most readily observed when conducting solubility measurements in the laboratory:

1. Surfactants
2. Cosolvents
3. Hydrotropic agents
4. pH and salt formation

1. the solubility but not the dissolution rate
2. the dissolution rate but not the solubility
3. both the solubility and dissolution rate
4. neither the solubility nor the dissolution rate

 
ANSWERS: C, A, B, C

Need to brush up on your knowledge? Check out the AAPS ecourse Formulation Strategies for Oral Delivery of  Poorly Soluble Drugs . The presentations highlight fundamental principles and enabling technologies for solubility enhancement, covering solid and liquid formulations and regulatory considerations.