Pharmaceutical Research Article Highlight on LNPs Used for Gene Delivery

Continuing the highly cited review published in 2023 titled "Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery," Prof. Zheng-Rong Liu and his co-authors have written a sequel: "Mechanism of pH-sensitive Amphiphilic Endosomal Escape of Ionizable Lipid Nanoparticles for Cytosolic Nucleic Acid Delivery", a new review published in the July issue of Pharmaceutical Research. 

The article aims to provide further insights into the cellular uptake mechanisms of lipid nanoparticles (LNPs) used for gene delivery. The article focuses on discussing a new strategy of utilizing ionizable lipids to formulate LNPs that achieve pH-sensitive amphiphilic membrane disruption and endosomal escape of delivered nucleic acids. This critical review is highly recommended for anyone conducting drug delivery research.