Spring 2019 Workshops Announced: Register Today!
Novel Approaches Targeting Brain Barriers for Effective Delivery of Therapeutics
April 29–May 1, 2019
Herndon, Va.
Cosponsored by
This program will focus on novel science, insights, tools, and approaches for targeting and bypassing the central nervous system (CNS) barriers to achieve drug delivery to the brain and spinal cord. Specialized barriers between the CNS and the bloodstream include the blood-brain barrier and the blood-cerebrospinal fluid barriers, among others. Highly limited paracellular transport and the expression of numerous efflux transporters at these key endothelial and epithelial interfaces pose major challenges to successful brain delivery of both small and large molecule therapeutics.
The goal of this workshop is to both clarify the main issues for the field and discuss the most cutting-edge current and future strategies for CNS drug delivery. The program will bring together international experts and junior investigators from academia, government (i.e., regulators), and industry and provide a format promoting exchange of new ideas and brainstorming novel solutions to existing challenges.
Specific themes for the workshop will cover the following topics:
- Physiology and regulation of CNS barriers
- Molecular mechanisms of brain permeability and targeting
- Novel CNS targeting strategies for crossing and bypassing the barriers
- Models and in vitro-in vivo correlations
See more of the agenda and speakers and register.
AAPS Forum to Connect Predictive Modelers
May 6–7, 2019
Boston, Mass.
Modeling and simulation as a discipline exists in many areas of the pharmaceutical sciences, including drug discovery, manufacturing, development, and patient use. Although niche workshops and conferences exist where predictive modelers meet and discuss specialized state-of-the art techniques and tools within their specific field, rarely do we cross outside of our area of expertise and engage with modelers in other pharma disciplines. There are many opportunities for education and collaboration that are missed because we are not talking enough with one another!
This workshop will bring together predictive modelers from academia, industry, and regulatory environments working in the pharmaceutical sciences. We will discover our commonalities and differences while sharing modeling philosophies and best practices. Focal points will include technical methodologies and tools as well as strategic approaches for communication and influence. We will be introduced to some of the latest predictive modeling tools and technologies to stimulate ideas for future development in all of our respective areas. The goal of this program is to identify opportunities to work together going forward to provide a more comprehensive and influential quantitative basis for decision making within our institutions.
Participants of this workshop will:
- compare and contrast tools, techniques, and language across predictive modeling disciplines in pharmaceutical sciences;
- discuss modeling philosophy and create best practices for predictive modeling;
- develop approaches for influencing decision makers through strategic communication of modeling results;
- discover state-of-the-art and emerging tools and technologies to motivate future development of predictive modeling in pharmaceutical sciences; and
- identify opportunities for collaboration, efficiency gain, and cross-discipline learning.
See more of the agenda and speakers and register.