2019 AAPS PharmSci 360

The Preclinical Track Themes Announced for 2019 AAPS PharmSci 360!

 

AAPS PharmSci 360 combines all the energy and resources of a large scientific conference with the content depth of a small bioanalytical gathering.

All of the scientific programming is themed—so jump into the track of your expertise and dive deep into your field’s hottest topics with your peers. Here are the themes for the preclinical development track:

THEME 1

Next Generation Technologies in Preclinical Development

This theme will explore recent advances in new technologies enabling improved or orthogonal drug discovery and preclinical assessments. 

Biomolecule subtrack sessions focusing on T-cell engaging molecules and CAR-T therapies may include, but are not limited to, target identification and selectivity, application of multispecifics in solid tumors, protein/cell engineering, avidity-driven molecule development, predictions of cytokine-release syndrome, achieving balanced T-cell activation, and recent case studies detailing challenges, success strategies, and lessons learned.

Chemical subtrack sessions focusing on artificial intelligence in drug discovery may include, but are not limited to, machine learning and deep/unsupervised learning, employing big data in computational drug repurposing/repositioning, advanced target scoring/identification, improved QSAR and drug property predictions, and recent applications in personalized medicine and rare disease.

THEME 2

Emerging Research Tools for High-Quality Candidate Selection

This theme will cover new developments in research tools critical for evaluating, derisking, and selecting optimal drug candidates.  This encompasses improved understanding and characterizing of biological systems, advances in function assays, and novel delivery strategies incorporating early stage fit-for-purpose models for formulation optimization.

For biomolecules, more specific topics may include, but are not limited to, deep sequencing to improve screening accuracy and robustness, enhanced immunogenicity predictions, advanced animal models, and imaging techniques for improving predictions.

For chemical entities, more specific topics may include but are not limited to applications of organ-on-a-chip models; gut microbiome studies; innovations in absorption, distribution, metabolism, and excretion and transporter assessments; and regulatory considerations in the preclinical space.

THEME 3

PK and PD Modeling in Effective Preclinical to Clinical Translation

This theme will delve into the state of the art regarding applications and implications of pharmacokinetics/pharmacodynamics (PK/PD) modeling and simulation including toxicodynamic aspects for therapeutic index assessment, first-in-human dose projections, biomarker-based clinical response predictions, improved drug-drug interaction liability assessments, covariate analysis in translation, advanced systems pharmacology modeling, and model-driven go/no-go decisions.

Biomolecular sessions will focus on multispecifics, CAR-Ts, and novel drug modalities including immunological markers within PK/PD models, and specific PK/PD models for combination products.

Chemical sessions will focus on advances in physiological-based modeling and simulation regarding preformulation, efficacy and safety predictions, and specific PK/PD models for combination products.

Register today!

See the programming tracks and keynote speakers for all tracks.

CONSIDER PRESENTING A RAPID FIRE IN 2019!

Rapid Fires are quick, 10-minute presentations with three minutes of Q&A on the latest scientific topics. Do you have research or ideas that are novel and exciting? Share them on the Rapid Fires stage!

Submission Deadline: July 5th at 5 pm ET

Submit your idea today!

Learning Is Large in the Solution Center

AAPS is expanding the scientific and career programming on the Solution Center floor to make your PhamSci 360 experience even more beneficial and diverse. Be sure to include time in your schedule to visit and take part in some or all of these unique educational opportunities.

The Solution Center Features:

• Rapid Fires: Back by popular demand! From 3 to 5 pm every day, each track will feature a series of quick, informal presentations on almost any topic.

• Tech Challenges: Participate in a peer competition for the best presentation of new and innovative technologies through an application-based case study. Vote on your favorite, and the top technologies will face off before the Solution Center closes on Wednesday.

• Software Lab: Bring your laptop to this hands-on, interactive event as companies demonstrate their latest software technology. Preregistration is required.

• Partner Presentations: Learn from AAPS’ exhibiting partners as they present case studies and speaker panels in their areas of expertise, and pose your questions about their products and services, face to face.

• Career Development Classroom: This year’s focus is on strategic leadership, managing your career in a rapidly changing work environment, and working with other organizations, including potential clients and partners.

Learn more

Announcing the 2019 PharmSci 360 End-to-End Topics!

Attendees will be able to follow each of these topics through the drug development process with symposia sessions in each of the five scientific tracks!

BIOMOLECULAR
Nucleic Acid-Based Therapeutics: Discovery, Development, and Delivery

This topic will follow the implementation pathway for a nucleic acid therapeutic from the initial therapeutic concept through to a finished product for patients. Topics may include: target identification, design and selection of clinical leads, preclinical ADME and PK/PD, biomarkers, routes of administration, bioanalytical plans, immunogenicity concerns, exposure-response and dose selection, formulation and analytical characterization, unique delivery aspects including viral vectors and exosomes, specialized manufacturing, and regulatory considerations.

CHEMICAL
The Journey to Developing Tissue- and Organ-Specific Therapies

This topic will explore some of the unique challenges and opportunities across all five scientific tracks of developing medicines for diseases within specific types of tissues or organs such as ocular, brain, tumor, and lung. Sessions will focus on strategies and techniques to overcome barriers and access target tissues, approaches to determining local drug exposures at the intended target, specialized administration processes, novel delivery devices, and unique regulatory considerations.

2019 Land O’Lakes Conferences

Developed and conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison, and in partnership with AAPS.

20th Annual Bioanalytical Conference

July 15 – 19, 2019

Innovation in Bioanalytical Research for Translational Medicine: New Modalities, New Technologies, and Evolving Regulations

This conference is designed to advance topics related to bioanalysis such as xenobiotics, metabolites, biologics, and biomarkers. An optional short course, Gene Therapy Fundamentals, is available. This year’s conference covers gene therapy, multiomics miniaturization, and bioanalysis regulation.

59th Annual Pharmaceutical Analysis Conference

Addressing Technical and Regulatory Challenges in Pharmaceutical Analysis

Learn about statistical techniques and their applications in the pharmaceutical industry at this conference, which will focus on navigating the technical and regulatory challenges. Industry leaders and regulators will present and answer the most common questions. Plenary sessions include the following: 

• Current Challenges to Pharmaceutical Analysis
• Focus on Large Molecules
• New Technologies and Approaches for Increasing Laboratory Efficiency
• Global Regulatory Challenges to Pharmaceutical Analysis 

22nd Annual Drug Metabolism and Applied Pharmacokinetics Conference

September 9 – 12, 2019

Found in Translation: Adaptive DMPK Strategies

Address drug safety evaluation and other topics related to drug metabolism and pharmacokinetics. There will be an optional short course on “Human Dose Projections.” This year we will discuss absorption, distribution, metabolism, and elimination in pharmacokinetics and pharmacodynamics. Plenary sessions include the following topics:

LEARN MORE & REGISTER